NURS 6630 Week 2 Discussion – Step-by-Step Guide
The first step before starting to write the NURS 6630 Week 2 Discussion: Foundational Neuroscience, it is essential to understand the requirements of the assignment. The first step is to read the assignment prompt carefully to identify the topic, the length and format requirements. You should go through the rubric provided so that you can understand what is needed to score the maximum points for each part of the assignment. It is also important to identify the audience of the paper and its purpose so that it can help you determine the tone and style to use throughout. You can then create a timeline to help you complete each stage of the paper, such as conducting research, writing the paper, and revising it to avoid last-minute stress before the deadline. After identifying the formatting style to be applied to the paper, such as APA, you should review its use, such as writing citations and referencing the resources used. You should also review how to format the title page and the headings in the paper.
How to Research and Prepare for NURS 6630 Week 2 Discussion
The next step in preparing for your paper is to conduct research and identify the best sources to use to support your arguments. Identify the list of keywords from your topic using different combinations. The first step is to visit the university library and search through its database using the important keywords related to your topic. You can also find books, peer-reviewed articles, and credible sources for your topic from PubMed, JSTOR, ScienceDirect, SpringerLink, and Google Scholar. Ensure that you select the references that have been published in the last words and go through each to check for credibility.
Ensure that you obtain the references in the required format, for example, in APA, so that you can save time when creating the final reference list. You can also group the references according to their themes that align with the outline of the paper. Go through each reference for its content and summarize the key concepts, arguments and findings for each source. You can write down your reflections on how each reference connects to the topic you are researching about. After the above steps, you can develop a strong thesis that is clear, concise and arguable. Next you should create a detailed outline of the paper so that it can help you to create headings and subheadings to be used in the paper. Ensure that you plan what point will go into each paragraph.
How to Write the Introduction for NURS 6630 Week 2 Discussion
The introduction of the paper is the most crucial part as it helps to provide the context of your work, and will determine if the reader will be interested to read through to the end. You should start with a hook, which will help capture the reader’s attention. You should contextualize the topic by offering the reader a concise overview of the topic you are writing about so that they may understand its importance. You should state what you aim to achieve with the paper. The last part of the introduction should be your thesis statement, which provides the main argument of the paper.
How to Write the Body for NURS 6630 Week 2 Discussion
The body of the paper helps you to present your arguments and evidence to support your claims. You can use headings and subheadings developed in the paper’s outline to guide you on how to organize the body. Start each paragraph with a topic sentence to help the reader know what point you will be discussing in that paragraph. Support your claims using the evidence conducted from the research, ensure that you cite each source properly using in-text citations. You should analyze the evidence presented and explain its significance and how it connects to the thesis statement. You should maintain a logical flow between each paragraph by using transition words and a flow of ideas.
How to Write the In-text Citations for NURS 6630 Week 2 Discussion
In-text citations help the reader to give credit to the authors of the references they have used in their works. All ideas that have been borrowed from references, any statistics and direct quotes must be referenced properly. The name and date of publication of the paper should be included when writing an in-text citation. For example, in APA, after stating the information, you can put an in-text citation after the end of the sentence, such as (Smith, 2021). If you are quoting directly from a source, include the page number in the citation, for example (Smith, 2021, p. 15). Remember to also include a corresponding reference list at the end of your paper that provides full details of each source cited in your text. An example paragraph highlighting the use of in-text citations is as below:
The integration of technology in nursing practice has significantly transformed patient care and improved health outcomes. According to Smith (2021), the use of electronic health records (EHRs) has streamlined communication among healthcare providers, allowing for more coordinated and efficient care delivery. Furthermore, Johnson and Brown (2020) highlight that telehealth services have expanded access to care, particularly for patients in rural areas, thereby reducing barriers to treatment.
How to Write the Conclusion for NURS 6630 Week 2 Discussion
When writing the conclusion of the paper, start by restarting your thesis, which helps remind the reader what your paper is about. Summarize the key points of the paper, by restating them. Discuss the implications of your findings and your arguments. End with a call to action that leaves a lasting impact on the reader or recommendations. Now that you have learned of foundational neuroscience, the following task is a self-assessment, to be completed in week 3 of NURS 6630.
How to Format the Reference List for NURS 6630 Week 2 Discussion
The reference helps provide the reader with the complete details of the sources you cited in the paper. The reference list should start with the title “References” on a new page. It should be aligned center and bolded, in sentence sentence care. The references should be organized in an ascending order alphabetically and each should have a hanging indent. If a source has no author, it should be alphabetized by the title of the work, ignoring any initial articles such as “A,” “An,” or “The.” If you have multiple works by the same author, list them in chronological order, starting with the earliest publication.
Each reference entry should include specific elements depending on the type of source. For books, include the author’s last name, first initial, publication year in parentheses, the title of the book in italics, the edition (if applicable), and the publisher’s name. For journal articles, include the author’s last name, first initial, publication year in parentheses, the title of the article (not italicized), the title of the journal in italics, the volume number in italics, the issue number in parentheses (if applicable), and the page range of the article. For online sources, include the DOI (Digital Object Identifier) or the URL at the end of the reference. An example reference list is as follows:
References
Johnson, L. M., & Brown, R. T. (2020). The role of telehealth in improving patient outcomes. Journal of Nursing Care Quality, 35(2), 123-130. https://doi.org/10.1097/NCQ.0000000000000456
Smith, J. A. (2021). The impact of technology on nursing practice. Health Press.
An Example NURS 6630 Week 2 Discussion Follows:
Foundational Neuroscience – Neurotransmitters and Receptor Theory
Neurotransmitters mediate the transmission of electrical impulses from one neuron to another. Multiple neurotransmitters are involved in central nervous system function, including amines (catecholamines, acetylcholine, and serotonin), amino acids (GABA, aspartate, and glutamate), peptides (neuropeptide Y), and gases such as nitric oxide (Sheffler et al., 2022). As discussed further, psychopharmacologic medications bind to specific neurotransmitter receptors, either activating (agonistic) or inhibiting (antagonistic).
Agonist-to-Antagonist Spectrum of Action of Psychopharmacologic Agents
Psychopharmacologic agents are useful in the treatment of a variety of psychiatric disorders, including mood disorders, trauma and stressor disorders, behavioral disorders, and psychotic disorders. The drugs exhibit either agonistic or antagonistic activity when acting at the receptor site. Whereas agonists bind to and activate a receptor to produce specific actions, antagonists bind to and block specific actions or responses (Katzung, 2018; Stern et al., 2015). The dopamine hypothesis, for example, is widely accepted in the etiology of schizophrenia. Excessive dopaminergic transmission is thought to be responsible for schizophrenic symptoms, and research has found higher levels of dopaminergic receptors in schizophrenic patients (Stahl, 2018). This epiphany is why psychopharmacologic agents that block Dopamine receptors, such as chlorpromazine, are used to treat schizophrenia. In contrast, neurodegenerative diseases such as Parkinson’s Disease (PD) have been linked to decreased dopamine levels and receptors, which is why dopamine agonists such as Levodopa are used to treat it.
Partial agonists bind to and activate receptors but have only partial efficacy. Partial agonists exhibit both agonistic and antagonistic actions, such as Buspirone, a partial agonist for 5HTA1 receptors and an antagonist for D2 receptors (Katzung, 2018). As a result, Buspirone can be used as both an anxiolytic and an antidepressant medication. Conversely, inverse agonists bind to receptors to produce effects opposite to those of the agonist (Katzung, 2018). Naltrexone is an example of a partial inverse agonist that is used to treat opioid addiction.
G-coupled Proteins and Ion-gated Channels
G-coupled proteins and Ion-gated chandelles are both cell surface receptors. To release ions, ligand-gated ion channels are controlled by neurotransmitters, whereas G-coupled receptors are entirely dependent on the second messenger system (Miller & Lappin, 2022). Because of the differences in stimulation mechanisms, the receptors take varying amounts of time to activate. While ligand-gated ion channels are activated in milliseconds, G-coupled protein receptors take seconds (Miller & Lappin, 2022). Furthermore, nicotinic acetylcholine receptors and GABA A receptors are examples of ligand-gated ion channels, whereas G-coupled receptors include muscarinic acetylcholine receptors and adrenoceptors (Katzung, 2018; Miller & Lappin, 2020). Regardless of the differences, receptors are critical in carrying out physiologic functions at the molecular level.
Role of Epigenetics in Pharmacologic Action
Genes play an essential role in the body, and so do behaviors and the environment. Epigenetics is the study of how behavior and environment influence gene expression (CDC, 2022). Unlike genetic changes, epigenetic changes are reversible and alter how the body reads the DNA sequence rather than changing the DNA sequence itself. The epigenetic changes may influence the pharmacology of certain drugs. Brain-Derived Neurotrophic Factor (BDNF), for example, promotes neuronal survival and synaptic plasticity and is involved in learning, memory, and neurotransmitter release (Webb et al., 2020). BDNF is expressed differently across brain regions depending on environmental stressors, ushering in the concept of epigenetics. Human studies show that BDNF brain levels decrease in untreated major depressive illness and increase with antidepressant treatment (Webb et al., 2020). As a result, BDNF has emerged as a viable candidate for predicting response to antidepressant therapy.
Significance of the Information
Information regarding the pharmacology of drugs is critical in healthcare. In addition to understanding disease mechanisms, psychiatric mental health nurse practitioners (PMHNP) must be proficient in drug pharmacology knowledge. For example, in the etiology of PD, the PMHNP is aware of the link between the disease and Dopamine. As a result, a PMHNP may decide to prescribe a Dopamine agonist, such as Levodopa, rather than a Dopamine antagonist, which would worsen the symptoms. Additionally, the pharmacology of a drug allows PMHNPs to understand the potential side effects of a drug. In the treatment of schizophrenia, for example, 12.5-50 mg of Risperidone may be injected into the deltoid or gluteal muscle every two weeks (McNeil et al., 2022), and a nurse should be aware that it is capable of causing extrapyramidal side effects, so the treatment should be used with caution. The information thus improves the way nurses perform their duties, resulting in better patient outcomes.
Conclusion
It is imperative for a PMHNP to have a concrete background in neuroscience. Understanding the pathophysiology of the disease is important in treating psychiatric patients, but knowledge of the medications used to treat the conditions is far more critical. This enables PMHNPs to practice competently and with full practice authority, even in the absence of a supervising psychiatrist consultant. While foundational neuroscience can be challenging to grasp, interacting with colleagues and patients broadens one’s understanding and alleviates the agony of trying to decipher complex concepts.
NURS 6630 Week 2 Discussion References
CDC. (2022, August 15). What is epigenetics? Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/epigenetics.htm
Katzung, B. G. (2018). Basic & Clinical Pharmacology. Basic & Clinical Pharmacology.
McNeil, S. E., Gibbons, J. R., & Cogburn, M. (2022). Risperidone. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK459313/
Miller, E. J., & Lappin, S. L. (2022). Physiology, Cellular Receptor. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK554403/
Sheffler, Z. M., Reddy, V., & Pillarisetty, L. S. (2022). Physiology, Neurotransmitters. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK539894/
Stahl, S. M. (2018). Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate. CNS Spectrums, 23(3), 187–191. https://doi.org/10.1017/S1092852918001013
Stern, T. A., Fava, M., Wilens, T. E., & Rosenbaum, J. F. (2015). Massachusetts general hospital psychopharmacology and neurotherapeutics. Elsevier Health Sciences.
Webb, L. M., Phillips, K. E., Ho, M. C., Veldic, M., & Blacker, C. J. (2020). The relationship between DNA methylation and antidepressant medications: A systematic review. International Journal of Molecular Sciences, 21(3), 826. https://doi.org/10.3390/ijms21030826
Frequently Asked Questions (FAQs)
When approaching a 500-word essay, it’s essential to understand the nuances of this compact form of writing. These frequently asked questions will guide you through the process of crafting a concise and impactful essay.
How many pages is a 500-word essay typically?
A 500-word essay usually spans about one page if single-spaced or two pages when double-spaced, with standard margins and a 12-point font size.
Can you provide examples of a well-structured 500-word essay?
Certainly, to see the structure and flow of a well-written essay, you might want to take a look at a student’s writing guide that provides insights and examples.
Are there specific formatting guidelines for a 500-word essay?
Formatting guidelines typically involve using a legible font like Times New Roman or Arial, size 12, with double-spacing and one-inch margins on all sides. Check any specific requirements your instructor might have provided.
What are some effective strategies for writing a personal essay of 500 words?
For a personal essay, focus on a singular event or characteristic, ensuring your ideas are clear and you reflect on the significance of the subject matter. Use concise language and powerful imagery to maximize impact.
What topics are suitable for a concise 500-word essay?
Choose topics you can thoroughly address within the word limit, such as a personal anecdote, a critical analysis of a poem, or a focused argument on a singular point or issue.
How much time should you allocate to write a 500-word essay effectively?
Depending on your familiarity with the topic and writing proficiency, allocate anywhere from one to several hours for planning, drafting, and revising to ensure a well-presented essay.
